Brain Death Determination: Still a Lot to Learn, Still a Lot to Do…

Nonthoracotomy defibrillator lead systems. A welcomed addition but still a lot to learn.

Shared mechanisms of ischaemic and haemorrhagic stroke: still a lot to learn.

T he risk of intracerebral haemorrhage (ICH) is increased in patients with ischaemic cerebrovascular disease and vice versa. Risk factors shared by both stroke subtypes, such as hypertension, age, and smoking, partly explain this observation. While some researchers stress that most ischaemic stroke subtypes have similar risk factor profiles, one can go further and claim that most strokes (ischa...

Chemoprevention with Vitamins and Minerals: There’s Still A Lot to Learn

The health benefits of adequate intake of vitamins, minerals and a host of other natural products are supported by extensive epidemiological data and have become a mainstay of nutritional counseling. The potential for some of these nutrients to reduce cancer mortality is particularly important for patients whose cancer has metastasized and have poor prognosis. Furthermore, efforts to develop vi...

Therapeutic hypothermia in Italian Intensive Care Units after 2010 resuscitation guidelines: still a lot to do.

BACKGROUND Therapeutic hypothermia (TH) is one of three interventions that have demonstrated to improve patients' neurological outcome after cardiac arrest. The aim of this study was to investigate the effect of the 2010 resuscitation guidelines on TH implementation in various Italian Intensive Care Units (ICU). METHODS A structured questionnaire was submitted to Italian ICU. The questionnair...

Sending proteins to dense core secretory granules: still a lot to sort out

The intracellular sorting of peptide hormone precursors to the dense core secretory granules (DCSGs) is essential for their bioactivation. Despite the fundamental importance of this cellular process, the nature of the sorting signals for entry of proteins into DCSGs remains a source of vigorous debate. This review highlights recent discoveries that are consistent with a model in which several p...